TPMT, COMT and ACYP2 genetic variants in paediatric cancer patients with cisplatin-induced ototoxicity

OBJECTIVES: Cisplatin ototoxicity affects 42-88% of treated children. COMT, TPMT, and AYCP2 genetic variants have been associated with ototoxicity, but the findings have been contradictory. The aims of the study were to (a) investigate these associations in a carefully phenotyped cohort of UK childr...

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Detalhes bibliográficos
Publicado no:Pharmacogenet Genomics
Main Authors: Thiesen, Signe, Yin, Peng, Jorgensen, Andrea L, Zhang, Jieying Eunice, Manzo, Valentina, McEvoy, Laurence, Barton, Christopher, Picton, Susan, Bailey, Simon, Brock, Penelope, Vyas, Harish, Walker, David, Makin, Guy, Bandi, Srinivas, Pizer, Barry, Hawcutt, Daniel B, Pirmohamed, Munir
Formato: Artigo
Idioma:Inglês
Publicado em: 2017
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Article
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC5432027/
https://ncbi.nlm.nih.gov/pubmed/28445188
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1097/FPC.0000000000000281
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