Intranasal drug delivery of small interfering RNA targeting Beclin1 encapsulated with polyethylenimine (PEI) in mouse brain to achieve HIV attenuation

We previously reported that activation of the host autophagic protein, Beclin1, by HIV-1 infection represents an essential mechanism in controlling HIV replication and viral-induced inflammatory responses in microglial cells. Existing antiretroviral therapeutic approaches have been limited in their...

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Udgivet i:Sci Rep
Main Authors: Rodriguez, Myosotys, Lapierre, Jessica, Ojha, Chet Raj, Kaushik, Ajeet, Batrakova, Elena, Kashanchi, Fatah, Dever, Seth M., Nair, Madhavan, El-Hage, Nazira
Format: Artigo
Sprog:Inglês
Udgivet: Nature Publishing Group UK 2017
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Article
Online adgang:https://ncbi.nlm.nih.gov/pmc/articles/PMC5431946/
https://ncbi.nlm.nih.gov/pubmed/28500326
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/s41598-017-01819-9
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