Intranasal drug delivery of small interfering RNA targeting Beclin1 encapsulated with polyethylenimine (PEI) in mouse brain to achieve HIV attenuation

We previously reported that activation of the host autophagic protein, Beclin1, by HIV-1 infection represents an essential mechanism in controlling HIV replication and viral-induced inflammatory responses in microglial cells. Existing antiretroviral therapeutic approaches have been limited in their...

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Vydáno v:Sci Rep
Hlavní autoři: Rodriguez, Myosotys, Lapierre, Jessica, Ojha, Chet Raj, Kaushik, Ajeet, Batrakova, Elena, Kashanchi, Fatah, Dever, Seth M., Nair, Madhavan, El-Hage, Nazira
Médium: Artigo
Jazyk:Inglês
Vydáno: Nature Publishing Group UK 2017
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Article
On-line přístup:https://ncbi.nlm.nih.gov/pmc/articles/PMC5431946/
https://ncbi.nlm.nih.gov/pubmed/28500326
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/s41598-017-01819-9
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