HIF-1α acts as a molecular target for simvastatin cytotoxicity in B16.F10 melanoma cells cultured under chemically induced hypoxia

Our previous studies reported that one of the main mechanisms of the antitumor activity of simvastatin (SIM) in B16.F10 murine melanoma cells was associated with strong suppression of the constitutive cell production of the α subunit of the heterodimeric transcription factor hypoxia-inducible factor...

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Detalhes bibliográficos
Publicado no:Oncol Lett
Main Authors: Licarete, Emilia, Sesarman, Alina, Rauca, Valentin Florian, Luput, Lavinia, Patras, Laura, Banciu, Manuela
Formato: Artigo
Idioma:Inglês
Publicado em: D.A. Spandidos 2017
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Articles
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC5431316/
https://ncbi.nlm.nih.gov/pubmed/28521491
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.3892/ol.2017.5928
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