The SWI/SNF Protein PBRM1 Restrains VHL Loss-Driven Clear Cell Renal Cell Carcinoma

PBRM1 is the second most commonly mutated gene after VHL in clear cell renal cell carcinoma (ccRCC). However, the biological consequences of PBRM1 mutations for kidney tumorigenesis are unknown. Here, we find that kidney-specific deletion of Vhl and Pbrm1, but not either gene alone, results in bilat...

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Udgivet i:Cell Rep
Main Authors: Nargund, Amrita M., Pham, Can G., Dong, Yiyu, Wang, Patricia I., Osmangeyoglu, Hatice U., Xie, Yuchen, Aras, Omer, Han, Song, Oyama, Toshinao, Takeda, Shugaku, Ray, Chelsea E., Dong, Zhenghong, Berge, Mathieu, Hakimi, A Ari, Monette, Sebastien, Lekaye, Carl L., Koutcher, Jason A., Leslie, Christina S., Creighton, Chad J., Weinhold, Nils, Lee, William, Tickoo, Satish K., Wang, Zhong, Cheng, Emily H., Hsieh, James J.
Format: Artigo
Sprog:Inglês
Udgivet: 2017
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Article
Online adgang:https://ncbi.nlm.nih.gov/pmc/articles/PMC5431084/
https://ncbi.nlm.nih.gov/pubmed/28329682
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.celrep.2017.02.074
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