The SWI/SNF Protein PBRM1 Restrains VHL Loss-Driven Clear Cell Renal Cell Carcinoma

PBRM1 is the second most commonly mutated gene after VHL in clear cell renal cell carcinoma (ccRCC). However, the biological consequences of PBRM1 mutations for kidney tumorigenesis are unknown. Here, we find that kidney-specific deletion of Vhl and Pbrm1, but not either gene alone, results in bilat...

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書誌詳細
出版年:Cell Rep
主要な著者: Nargund, Amrita M., Pham, Can G., Dong, Yiyu, Wang, Patricia I., Osmangeyoglu, Hatice U., Xie, Yuchen, Aras, Omer, Han, Song, Oyama, Toshinao, Takeda, Shugaku, Ray, Chelsea E., Dong, Zhenghong, Berge, Mathieu, Hakimi, A Ari, Monette, Sebastien, Lekaye, Carl L., Koutcher, Jason A., Leslie, Christina S., Creighton, Chad J., Weinhold, Nils, Lee, William, Tickoo, Satish K., Wang, Zhong, Cheng, Emily H., Hsieh, James J.
フォーマット: Artigo
言語:Inglês
出版事項: 2017
主題:
Article
オンライン･アクセス:https://ncbi.nlm.nih.gov/pmc/articles/PMC5431084/
https://ncbi.nlm.nih.gov/pubmed/28329682
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.celrep.2017.02.074
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