Xanthine oxidase inhibition by febuxostat attenuates stress-induced hyperuricemia, glucose dysmetabolism, and prothrombotic state in mice

Chronic stress is closely linked to the metabolic syndrome, diabetes, hyperuricemia and thromboembolism, but the mechanisms remain elusive. We reported recently that stress targets visceral adipose tissue (VAT), inducing lipolysis, low-grade inflammation with production of inflammatory adipokines, m...

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Published in:Sci Rep
Main Authors: Yisireyili, Maimaiti, Hayashi, Motoharu, Wu, Hongxian, Uchida, Yasuhiro, Yamamoto, Koji, Kikuchi, Ryosuke, Shoaib Hamrah, Mohammad, Nakayama, Takayuki, Wu Cheng, Xian, Matsushita, Tadashi, Nakamura, Shigeo, Niwa, Toshimitsu, Murohara, Toyoaki, Takeshita, Kyosuke
Format: Artigo
Language:Inglês
Published: Nature Publishing Group UK 2017
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Online Access:https://ncbi.nlm.nih.gov/pmc/articles/PMC5430858/
https://ncbi.nlm.nih.gov/pubmed/28455534
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/s41598-017-01366-3
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