Differential regulation of PKD isoforms in oxidative stress conditions through phosphorylation of a conserved Tyr in the P+1 loop

Protein kinases are essential molecules in life and their crucial function requires tight regulation. Many kinases are regulated via phosphorylation within their activation loop. This loop is embedded in the activation segment, which additionally contains the Mg(2+) binding loop and a P + 1 loop tha...

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Pubblicato in:Sci Rep
Autori principali: Cobbaut, Mathias, Derua, Rita, Döppler, Heike, Lou, Hua Jane, Vandoninck, Sandy, Storz, Peter, Turk, Benjamin E., Seufferlein, Thomas, Waelkens, Etienne, Janssens, Veerle, Van Lint, Johan
Natura: Artigo
Lingua:Inglês
Pubblicazione: Nature Publishing Group UK 2017
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Article
Accesso online:https://ncbi.nlm.nih.gov/pmc/articles/PMC5430542/
https://ncbi.nlm.nih.gov/pubmed/28428613
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/s41598-017-00800-w
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