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Targeting amino acid metabolism for cancer therapy
To support sustained biomass accumulation, tumor cells undergo metabolic reprogramming. Nutrient transporters and metabolic enzymes are regulated by the same oncogenic signals that drive cell-cycle progression. Some of the earliest cancer therapies used antimetabolites to disrupt tumor metabolism, a...
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| Τόπος έκδοσης: | Drug Discov Today |
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| Κύριοι συγγραφείς: | , , |
| Μορφή: | Artigo |
| Γλώσσα: | Inglês |
| Έκδοση: |
2016
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| Θέματα: | |
| Διαθέσιμο Online: | https://ncbi.nlm.nih.gov/pmc/articles/PMC5429979/ https://ncbi.nlm.nih.gov/pubmed/27988359 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.drudis.2016.12.003 |
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