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Targeting amino acid metabolism for cancer therapy

To support sustained biomass accumulation, tumor cells undergo metabolic reprogramming. Nutrient transporters and metabolic enzymes are regulated by the same oncogenic signals that drive cell-cycle progression. Some of the earliest cancer therapies used antimetabolites to disrupt tumor metabolism, a...

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Detalhes bibliográficos
Publicado no:Drug Discov Today
Main Authors: Lukey, Michael J., Katt, William P., Cerione, Richard A.
Formato: Artigo
Idioma:Inglês
Publicado em: 2016
Assuntos:
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC5429979/
https://ncbi.nlm.nih.gov/pubmed/27988359
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.drudis.2016.12.003
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