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Targeting amino acid metabolism for cancer therapy
To support sustained biomass accumulation, tumor cells undergo metabolic reprogramming. Nutrient transporters and metabolic enzymes are regulated by the same oncogenic signals that drive cell-cycle progression. Some of the earliest cancer therapies used antimetabolites to disrupt tumor metabolism, a...
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| Publicado no: | Drug Discov Today |
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| Main Authors: | , , |
| Formato: | Artigo |
| Idioma: | Inglês |
| Publicado em: |
2016
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| Assuntos: | |
| Acesso em linha: | https://ncbi.nlm.nih.gov/pmc/articles/PMC5429979/ https://ncbi.nlm.nih.gov/pubmed/27988359 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.drudis.2016.12.003 |
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