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Targeting amino acid metabolism for cancer therapy

To support sustained biomass accumulation, tumor cells undergo metabolic reprogramming. Nutrient transporters and metabolic enzymes are regulated by the same oncogenic signals that drive cell-cycle progression. Some of the earliest cancer therapies used antimetabolites to disrupt tumor metabolism, a...

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Bibliografische gegevens
Gepubliceerd in:Drug Discov Today
Hoofdauteurs: Lukey, Michael J., Katt, William P., Cerione, Richard A.
Formaat: Artigo
Taal:Inglês
Gepubliceerd in: 2016
Onderwerpen:
Online toegang:https://ncbi.nlm.nih.gov/pmc/articles/PMC5429979/
https://ncbi.nlm.nih.gov/pubmed/27988359
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.drudis.2016.12.003
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