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Discovery and characterization of verinurad, a potent and specific inhibitor of URAT1 for the treatment of hyperuricemia and gout

Gout is caused by elevated serum urate levels, which can be treated using inhibitors of the uric acid transporter, URAT1. Here, we characterize verinurad (RDEA3170), which is currently under evaluation for gout therapy. Verinurad specifically inhibits URAT1 with a potency of 25 nM. High affinity inh...

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Détails bibliographiques
Publié dans:Sci Rep
Auteurs principaux: Tan, Philip K., Liu, Sha, Gunic, Esmir, Miner, Jeffrey N.
Format: Artigo
Langue:Inglês
Publié: Nature Publishing Group UK 2017
Sujets:
Accès en ligne:https://ncbi.nlm.nih.gov/pmc/articles/PMC5429603/
https://ncbi.nlm.nih.gov/pubmed/28386072
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/s41598-017-00706-7
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