Loss of p27(kip1) increases genomic instability and induces radio-resistance in luminal breast cancer cells

Genomic instability represents a typical feature of aggressive cancers. Normal cells have evolved intricate responses to preserve genomic integrity in response to stress, such as DNA damage induced by γ-irradiation. Cyclin-dependent kinases (CDKs) take crucial part to these safeguard mechanisms, but...

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Détails bibliographiques
Publié dans:Sci Rep
Auteurs principaux: Berton, Stefania, Cusan, Martina, Segatto, Ilenia, Citron, Francesca, D’Andrea, Sara, Benevol, Sara, Avanzo, Michele, Dall’Acqua, Alessandra, Schiappacassi, Monica, Bristow, Robert G., Belletti, Barbara, Baldassarre, Gustavo
Format: Artigo
Langue:Inglês
Publié: Nature Publishing Group UK 2017
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Article
Accès en ligne:https://ncbi.nlm.nih.gov/pmc/articles/PMC5429596/
https://ncbi.nlm.nih.gov/pubmed/28377607
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/s41598-017-00734-3
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