Delivery of ENaC siRNA to epithelial cells mediated by a targeted nanocomplex: a therapeutic strategy for cystic fibrosis

The inhibition of ENaC may have therapeutic potential in CF airways by reducing sodium hyperabsorption, restoring lung epithelial surface fluid levels, airway hydration and mucociliary function. The challenge has been to deliver siRNA to the lung with sufficient efficacy for a sustained therapeutic...

Deskribapen osoa

Gorde:
Xehetasun bibliografikoak
Argitaratua izan da:Sci Rep
Egile Nagusiak: Manunta, Maria D. I., Tagalakis, Aristides D., Attwood, Martin, Aldossary, Ahmad M., Barnes, Josephine L., Munye, Mustafa M., Weng, Alexander, McAnulty, Robin J, Hart, Stephen L.
Formatua: Artigo
Hizkuntza:Inglês
Argitaratua: Nature Publishing Group UK 2017
Gaiak:
Article
Sarrera elektronikoa:https://ncbi.nlm.nih.gov/pmc/articles/PMC5428798/
https://ncbi.nlm.nih.gov/pubmed/28386087
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/s41598-017-00662-2
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