Delivery of ENaC siRNA to epithelial cells mediated by a targeted nanocomplex: a therapeutic strategy for cystic fibrosis

The inhibition of ENaC may have therapeutic potential in CF airways by reducing sodium hyperabsorption, restoring lung epithelial surface fluid levels, airway hydration and mucociliary function. The challenge has been to deliver siRNA to the lung with sufficient efficacy for a sustained therapeutic...

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Veröffentlicht in:Sci Rep
Hauptverfasser: Manunta, Maria D. I., Tagalakis, Aristides D., Attwood, Martin, Aldossary, Ahmad M., Barnes, Josephine L., Munye, Mustafa M., Weng, Alexander, McAnulty, Robin J, Hart, Stephen L.
Format: Artigo
Sprache:Inglês
Veröffentlicht: Nature Publishing Group UK 2017
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Article
Online Zugang:https://ncbi.nlm.nih.gov/pmc/articles/PMC5428798/
https://ncbi.nlm.nih.gov/pubmed/28386087
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/s41598-017-00662-2
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