Enhanced oral bioavailability of valsartan using a polymer-based supersaturable self-microemulsifying drug delivery system

A novel, supersaturable self-microemulsifying drug delivery system (S-SMEDDS) was successfully formulated to enhance the dissolution and oral absorption of valsartan (VST), a poorly water-soluble drug, while reducing the total quantity for administration. Poloxamer 407 is a selectable, supersaturati...

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Bibliographic Details
Published in:Int J Nanomedicine
Main Authors: Yeom, Dong Woo, Chae, Bo Ram, Son, Ho Yong, Kim, Jin Han, Chae, Jun Soo, Song, Seh Hyon, Oh, Dongho, Choi, Young Wook
Format: Artigo
Language:Inglês
Published: Dove Medical Press 2017
Subjects:
Original Research
Online Access:https://ncbi.nlm.nih.gov/pmc/articles/PMC5428796/
https://ncbi.nlm.nih.gov/pubmed/28507434
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.2147/IJN.S136599
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