SUMO-Specific Protease 1 (SENP1) Reverses the Hormone-Augmented SUMOylation of Androgen Receptor and Modulates Gene Responses in Prostate Cancer Cells

The acceptor sites for small ubiquitin-like modifier (SUMO) are conserved in the N-terminal domains of several nuclear receptors. Here, we show that androgens induce rapid and dynamic conjugation of SUMO-1 to androgen receptor (AR). Nuclear import of AR is not sufficient for SUMOylation, because con...

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Bibliographic Details
Published in:Mol Endocrinol
Main Authors: Kaikkonen, Sanna, Jääskeläinen, Tiina, Karvonen, Ulla, Rytinki, Miia M., Makkonen, Harri, Gioeli, Daniel, Paschal, Bryce M., Palvimo, Jorma J.
Format: Artigo
Language:Inglês
Published: Endocrine Society 2009
Subjects:
Original Research
Online Access:https://ncbi.nlm.nih.gov/pmc/articles/PMC5428156/
https://ncbi.nlm.nih.gov/pubmed/19116244
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1210/me.2008-0219
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