Local delivery of novel MRTF/SRF inhibitors prevents scar tissue formation in a preclinical model of fibrosis

The myocardin-related transcription factor/serum response factor (MRTF/SRF) pathway represents a promising therapeutic target to prevent fibrosis. We have tested the effects of new pharmacological inhibitors of MRTF/SRF signalling in a preclinical model of fibrosis. CCG-222740, a novel MRTF/SRF inhi...

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Vydáno v:Sci Rep
Hlavní autoři: Yu-Wai-Man, Cynthia, Spencer-Dene, Bradley, Lee, Richard M. H., Hutchings, Kim, Lisabeth, Erika M., Treisman, Richard, Bailly, Maryse, Larsen, Scott D., Neubig, Richard R., Khaw, Peng T.
Médium: Artigo
Jazyk:Inglês
Vydáno: Nature Publishing Group UK 2017
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Article
On-line přístup:https://ncbi.nlm.nih.gov/pmc/articles/PMC5428058/
https://ncbi.nlm.nih.gov/pubmed/28364121
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/s41598-017-00212-w
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