Targeting to the non-genomic activity of retinoic acid receptor-gamma by acacetin in hepatocellular carcinoma

We recently demonstrated that retinoic acid receptor-γ (RARγ) is overexpressed and acts as a tumor promoter in hepatocellular carcinoma (HCC). The oncogenic activity of RARγ is mainly attributed to its physiological interaction with p85α regulatory subunit of PI3K leading to constitutive activation...

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Detalhes bibliográficos
Publicado no:Sci Rep
Main Authors: Zeng, Wenjun, Zhang, Chunyun, Cheng, Hongwei, Wu, Yun-Long, Liu, Jie, Chen, Zekun, Huang, Jian-gang, Ericksen, Russell Erick, Chen, Liqun, Zhang, Haiping, Wong, Alice Sze Tsai, Zhang, Xiao-kun, Han, Weiping, Zeng, Jin-Zhang
Formato: Artigo
Idioma:Inglês
Publicado em: Nature Publishing Group UK 2017
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Article
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC5428017/
https://ncbi.nlm.nih.gov/pubmed/28336971
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/s41598-017-00233-5
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