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CCR5 promoter activity correlates with HIV disease progression by regulating CCR5 cell surface expression and CD4 T cell apoptosis

CCR5 is the major co-receptor for HIV and polymorphisms in the CCR5 gene as well as promoter region that alter cell surface expression have been associated with disease progression. We determined the relationship between CCR5 promoter polymorphisms and CD4 decline and other immunopathological featur...

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Detalhes bibliográficos
Publicado no:Sci Rep
Main Authors: Joshi, Anjali, Punke, Erin B., Sedano, Melina, Beauchamp, Bethany, Patel, Rima, Hossenlopp, Cassady, Alozie, Ogechika K., Gupta, Jayanta, Mukherjee, Debabrata, Garg, Himanshu
Formato: Artigo
Idioma:Inglês
Publicado em: Nature Publishing Group UK 2017
Assuntos:
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC5427887/
https://ncbi.nlm.nih.gov/pubmed/28331180
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/s41598-017-00192-x
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