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Combination gene therapy for HIV using a conditional suicidal gene with CCR5 knockout
BACKGROUND: Gene therapy approaches using hematopoietic stem cells to generate an HIV resistant immune system have been shown to be successful. The deletion of HIV co-receptor CCR5 remains a viable strategy although co-receptor switching to CXCR4 remains a major pitfall. To overcome this, we designe...
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| Udgivet i: | Virol J |
|---|---|
| Main Authors: | , , , |
| Format: | Artigo |
| Sprog: | Inglês |
| Udgivet: |
BioMed Central
2021
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| Fag: | |
| Online adgang: | https://ncbi.nlm.nih.gov/pmc/articles/PMC7847599/ https://ncbi.nlm.nih.gov/pubmed/33516234 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1186/s12985-021-01501-7 |
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