Combination gene therapy for HIV using a conditional suicidal gene with CCR5 knockout

BACKGROUND: Gene therapy approaches using hematopoietic stem cells to generate an HIV resistant immune system have been shown to be successful. The deletion of HIV co-receptor CCR5 remains a viable strategy although co-receptor switching to CXCR4 remains a major pitfall. To overcome this, we designe...

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Bibliographic Details
Published in:Virol J
Main Authors: Mehmetoglu-Gurbuz, Tugba, Yeh, Rose, Garg, Himanshu, Joshi, Anjali
Format: Artigo
Language:Inglês
Published: BioMed Central 2021
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Research
Online Access:https://ncbi.nlm.nih.gov/pmc/articles/PMC7847599/
https://ncbi.nlm.nih.gov/pubmed/33516234
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1186/s12985-021-01501-7
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