HIV-1 Env glycoprotein phenotype along with immune activation determines CD4 T cell loss in HIV patients

The mechanism behind the selective depletion of CD4(+) cells in HIV infections remains undetermined. Although HIV selectively infects CD4+ cells, the relatively few infected cells in vivo cannot account for the extent of CD4+ T cell depletion suggesting indirect or bystander mechanisms. The role of...

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Veröffentlicht in:J Immunol
Hauptverfasser: Joshi, Anjali, Sedano, Melina, Beauchamp, Bethany, Punke, Erin, Mulla, Zuber, Meza, Armando, Alozie, Ogechika, Mukherjee, Debabrata, Garg, Himanshu
Format: Artigo
Sprache:Inglês
Veröffentlicht: 2016
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Article
Online Zugang:https://ncbi.nlm.nih.gov/pmc/articles/PMC4744550/
https://ncbi.nlm.nih.gov/pubmed/26764036
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.4049/jimmunol.1501588
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