Yersinia effector protein (YopO)-mediated phosphorylation of host gelsolin causes calcium-independent activation leading to disruption of actin dynamics

Pathogenic Yersinia bacteria cause a range of human diseases. To modulate and evade host immune systems, these yersiniae inject effector proteins into host macrophages. One such protein, the serine/threonine kinase YopO (YpkA in Yersinia pestis), uses monomeric actin as bait to recruit and phosphory...

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Detalhes bibliográficos
Publicado no:J Biol Chem
Main Authors: Singaravelu, Pavithra, Lee, Wei Lin, Wee, Sheena, Ghoshdastider, Umesh, Ding, Ke, Gunaratne, Jayantha, Grimes, Jonathan M., Swaminathan, Kunchithapadam, Robinson, Robert C.
Formato: Artigo
Idioma:Inglês
Publicado em: American Society for Biochemistry and Molecular Biology 2017
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Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC5427284/
https://ncbi.nlm.nih.gov/pubmed/28280241
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1074/jbc.M116.757971
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