Sequestering of Rac by the Yersinia Effector YopO Blocks Fcγ Receptor-mediated Phagocytosis

Pathogenic Yersinia species neutralize innate immune mechanisms by injecting type three secretion effectors into immune cells, altering cell signaling. Our study elucidates how one of these effectors, YopO, blocks phagocytosis. We demonstrate using different phagocytic models that YopO specifically...

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Detalhes bibliográficos
Main Authors: Groves, Eleanor, Rittinger, Katrin, Amstutz, Marlise, Berry, Sara, Holden, David W., Cornelis, Guy R., Caron, Emmanuelle
Formato: Artigo
Idioma:Inglês
Publicado em: American Society for Biochemistry and Molecular Biology 2010
Assuntos:
Mechanisms of Signal Transduction
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC2823549/
https://ncbi.nlm.nih.gov/pubmed/19926792
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1074/jbc.M109.071035
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