Differential involvement of the microtubule cytoskeleton in insulin receptor substrate 1 (IRS-1) and IRS-2 signaling to AKT determines the response to microtubule disruption in breast carcinoma cells

The insulin receptor substrate (IRS) proteins serve as essential signaling intermediates for the activation of PI3K by both the insulin-like growth factor 1 receptor (IGF-1R) and its close family member, the insulin receptor (IR). Although IRS-1 and IRS-2 share significant homology, they regulate di...

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Detalhes bibliográficos
Publicado no:J Biol Chem
Main Authors: Mercado-Matos, Jose, Clark, Jennifer L., Piper, Andrew J., Janusis, Jenny, Shaw, Leslie M.
Formato: Artigo
Idioma:Inglês
Publicado em: American Society for Biochemistry and Molecular Biology 2017
Assuntos:
Signal Transduction
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC5427262/
https://ncbi.nlm.nih.gov/pubmed/28320862
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1074/jbc.M117.785832
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