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Large Animal Models of Huntington’s Disease
Huntington’s disease is caused by the expansion of a polyglutamine repeat (>37 glutamines) in the disease protein huntingtin, which results in preferential neuronal loss in distinct brain regions. Mutant huntingtin causes late-onset neurological symptoms in patients in middle life, though the exp...
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| Veröffentlicht in: | Curr Top Behav Neurosci |
|---|---|
| Hauptverfasser: | , |
| Format: | Artigo |
| Sprache: | Inglês |
| Veröffentlicht: |
2015
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| Schlagworte: | |
| Online Zugang: | https://ncbi.nlm.nih.gov/pmc/articles/PMC5426810/ https://ncbi.nlm.nih.gov/pubmed/24048953 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1007/7854_2013_246 |
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