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Distinct cellular toxicity of two mutant huntingtin mRNA variants due to translation regulation
Huntington’s disease (HD) is a neurodegenerative disorder caused by CAG repeat expansion within exon1 of the HTT gene. The gene generates two mRNA variants that carry either a short or long 3′ untranslated region (3′UTR) while encoding the same protein. It remains unknown whether the two mRNA varian...
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| Publicado no: | PLoS One |
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| Main Authors: | , , |
| Formato: | Artigo |
| Idioma: | Inglês |
| Publicado em: |
Public Library of Science
2017
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| Assuntos: | |
| Acesso em linha: | https://ncbi.nlm.nih.gov/pmc/articles/PMC5426682/ https://ncbi.nlm.nih.gov/pubmed/28494017 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1371/journal.pone.0177610 |
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