The cardiac glycoside ouabain activates NLRP3 inflammasomes and promotes cardiac inflammation and dysfunction

Cardiac glycosides such as digoxin are Na(+)/K(+)-ATPase inhibitors that are widely used for the treatment of chronic heart failure and cardiac arrhythmias; however, recent epidemiological studies have suggested a relationship between digoxin treatment and increased mortality. We previously showed t...

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Veröffentlicht in:PLoS One
Hauptverfasser: Kobayashi, Motoi, Usui-Kawanishi, Fumitake, Karasawa, Tadayoshi, Kimura, Hiroaki, Watanabe, Sachiko, Mise, Nathan, Kayama, Fujio, Kasahara, Tadashi, Hasebe, Naoyuki, Takahashi, Masafumi
Format: Artigo
Sprache:Inglês
Veröffentlicht: Public Library of Science 2017
Schlagworte:
Research Article
Online Zugang:https://ncbi.nlm.nih.gov/pmc/articles/PMC5426608/
https://ncbi.nlm.nih.gov/pubmed/28493895
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1371/journal.pone.0176676
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