Histone methyltransferase SETDB1 regulates liver cancer cell growth through methylation of p53

SETDB1 is a histone H3K9 methyltransferase that has a critical role in early development. It is located within a melanoma susceptibility locus and facilitates melanoma formation. However, the mechanism by which SETDB1 regulates tumorigenesis remains unknown. Here we report the molecular interplay be...

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Vydáno v:Nat Commun
Hlavní autoři: Fei, Qi, Shang, Ke, Zhang, Jianhua, Chuai, Shannon, Kong, Desheng, Zhou, Tianlun, Fu, Shijun, Liang, Ying, Li, Chong, Chen, Zhi, Zhao, Yuan, Yu, Zhengtian, Huang, Zheng, Hu, Min, Ying, Haiyan, Chen, Zhui, Zhang, Yun, Xing, Feng, Zhu, Jidong, Xu, Haiyan, Zhao, Kehao, Lu, Chris, Atadja, Peter, Xiao, Zhi-Xiong, Li, En, Shou, Jianyong
Médium: Artigo
Jazyk:Inglês
Vydáno: Nature Publishing Group 2015
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Article
On-line přístup:https://ncbi.nlm.nih.gov/pmc/articles/PMC5426523/
https://ncbi.nlm.nih.gov/pubmed/26471002
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/ncomms9651
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