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Enhanced sampling simulations to construct free-energy landscape of protein–partner substrate interaction

Molecular dynamics (MD) simulations using all-atom and explicit solvent models provide valuable information on the detailed behavior of protein–partner substrate binding at the atomic level. As the power of computational resources increase, MD simulations are being used more widely and easily. Howev...

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Detalhes bibliográficos
Publicado no:Biophys Rev
Main Authors: Ikebe, Jinzen, Umezawa, Koji, Higo, Junichi
Formato: Artigo
Idioma:Inglês
Publicado em: Springer Berlin Heidelberg 2016
Assuntos:
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC5425738/
https://ncbi.nlm.nih.gov/pubmed/28510144
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1007/s12551-015-0189-z
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