Contribution of thrombin-reactive brain pericytes to blood-brain barrier dysfunction in an in vivo mouse model of obesity-associated diabetes and an in vitro rat model

Diabetic complications are characterized by the dysfunction of pericytes located around microvascular endothelial cells. The blood–brain barrier (BBB) exhibits hyperpermeability with progression of diabetes. Therefore, brain pericytes at the BBB may be involved in diabetic complications of the centr...

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Detalhes bibliográficos
Publicado no:PLoS One
Main Authors: Machida, Takashi, Takata, Fuyuko, Matsumoto, Junichi, Miyamura, Tomoyuki, Hirata, Ryosuke, Kimura, Ikuya, Kataoka, Yasufumi, Dohgu, Shinya, Yamauchi, Atsushi
Formato: Artigo
Idioma:Inglês
Publicado em: Public Library of Science 2017
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Research Article
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC5425209/
https://ncbi.nlm.nih.gov/pubmed/28489922
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1371/journal.pone.0177447
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