In Vitro Blood-Brain Barrier Models Using Brain Capillary Endothelial Cells Isolated from Neonatal and Adult Rats Retain Age-Related Barrier Properties

The blood–brain barrier (BBB) restricts the entry of circulating drugs and xenobiotics into the brain, and thus its permeability to substances is a critical factor that determines their central effects. The infant brain is vulnerable to neurotoxic substances partly due to the immature BBB. The emplo...

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Main Authors: Takata, Fuyuko, Dohgu, Shinya, Yamauchi, Atsushi, Matsumoto, Junichi, Machida, Takashi, Fujishita, Kayoko, Shibata, Keisuke, Shinozaki, Youichi, Sato, Kaoru, Kataoka, Yasufumi, Koizumi, Schuichi
Format: Artigo
Jezik:Inglês
Izdano: Public Library of Science 2013
Teme:
Research Article
Online dostop:https://ncbi.nlm.nih.gov/pmc/articles/PMC3561369/
https://ncbi.nlm.nih.gov/pubmed/23383092
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1371/journal.pone.0055166
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