Aspirin inhibits the SHH/GLI1 signaling pathway and sensitizes malignant glioma cells to temozolomide therapy

Aberrant activation of sonic hedgehog (SHH)/glioma-associated oncogene homolog 1 (GLI1) pathway plays an important role in the tumorigenicity of malignant glioma cells and resistance to temozolomide (TMZ). Here we investigated the aspirin's antineoplastic molecular route by targeting SHH/GLI1 p...

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Bibliographic Details
Published in:Aging (Albany NY)
Main Authors: Ming, Jianguang, Sun, Bo, Li, Ziwei, Lin, Lin, Meng, Xiangqi, Han, Bo, Wang, Ruijia, Wu, Pengfei, Li, Jianlong, Cai, Jinquan, Jiang, Chuanlu
Format: Artigo
Language:Inglês
Published: Impact Journals LLC 2017
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Research Paper
Online Access:https://ncbi.nlm.nih.gov/pmc/articles/PMC5425124/
https://ncbi.nlm.nih.gov/pubmed/28446712
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.18632/aging.101224
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