Loss of BRCA1 in the cells of origin of ovarian cancer induces glycolysis: A window of opportunity for ovarian cancer chemoprevention

Mutations in the breast cancer susceptibility gene 1 (BRCA1) are associated with an increased risk of developing epithelial ovarian cancer. However, beyond the role of BRCA1 in DNA repair, little is known about other mechanisms by which BRCA1 impairment promotes carcinogenesis. Given that altered me...

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Publicat a:Cancer Prev Res (Phila)
Autors principals: Chiyoda, Tatsuyuki, Hart, Peter C., Eckert, Mark A., McGregor, Stephanie M., Lastra, Ricardo R., Hamamoto, Ryuji, Nakamura, Yusuke, Yamada, S. Diane, Olopade, Olufunmilayo I., Lengyel, Ernst, Romero, Iris L.
Format: Artigo
Idioma:Inglês
Publicat: 2017
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Article
Accés en línia:https://ncbi.nlm.nih.gov/pmc/articles/PMC5425093/
https://ncbi.nlm.nih.gov/pubmed/28264838
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1158/1940-6207.CAPR-16-0281
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