Bosentan and Rifampin Interactions Modulate Influx Transporter and Cytochrome P450 Expression and Activities in Primary Human Hepatocytes

The incidence of polypharmacy-which can result in drug-drug interactions-has increased in recent years. Drug-metabolizing enzymes and drug transporters are important polypharmacy modulators. In this study, the effects of bosentan and rifampin on the expression and activities of organic anion-transpo...

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Veröffentlicht in:Biomol Ther (Seoul)
Hauptverfasser: Han, Kyoung-Moon, Ahn, Sun-Young, Seo, Hyewon, Yun, Jaesuk, Cha, Hye Jin, Shin, Ji-Soon, Kim, Young-Hoon, Kim, Hyungsoo, Park, Hye-kyung, Lee, Yong-Moon
Format: Artigo
Sprache:Inglês
Veröffentlicht: The Korean Society of Applied Pharmacology 2017
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Original Article
Online Zugang:https://ncbi.nlm.nih.gov/pmc/articles/PMC5424639/
https://ncbi.nlm.nih.gov/pubmed/28173639
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.4062/biomolther.2016.153
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