Differences in the Epigenetic Regulation of Cytochrome P450 Genes between Human Embryonic Stem Cell-Derived Hepatocytes and Primary Hepatocytes

Human pluripotent stem cell-derived hepatocytes have the potential to provide in vitro model systems for drug discovery and hepatotoxicity testing. However, these cells are currently unsuitable for drug toxicity and efficacy testing because of their limited expression of genes encoding drug-metaboli...

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Detalhes bibliográficos
Publicado no:PLoS One
Main Authors: Park, Han-Jin, Choi, Young-Jun, Kim, Ji Woo, Chun, Hang-Suk, Im, Ilkyun, Yoon, Seokjoo, Han, Yong-Mahn, Song, Chang-Woo, Kim, Hyemin
Formato: Artigo
Idioma:Inglês
Publicado em: Public Library of Science 2015
Assuntos:
Research Article
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC4503736/
https://ncbi.nlm.nih.gov/pubmed/26177506
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1371/journal.pone.0132992
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