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Cataract-associated P23T γD-crystallin retains a native-like fold in amorphous-looking aggregates formed at physiological pH

Cataracts cause vision loss through the large-scale aggregation of eye lens proteins as a result of ageing or congenital mutations. The development of new treatments is hindered by uncertainty about the nature of the aggregates and their mechanism of formation. We describe the structure and morpholo...

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Bibliografiska uppgifter
I publikationen:Nat Commun
Huvudupphovsmän: Boatz, Jennifer C., Whitley, Matthew J., Li, Mingyue, Gronenborn, Angela M., van der Wel, Patrick C. A.
Materialtyp: Artigo
Språk:Inglês
Publicerad: Nature Publishing Group 2017
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Länkar:https://ncbi.nlm.nih.gov/pmc/articles/PMC5424181/
https://ncbi.nlm.nih.gov/pubmed/28474685
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/ncomms15137
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