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Cataract-associated P23T γD-crystallin retains a native-like fold in amorphous-looking aggregates formed at physiological pH

Cataracts cause vision loss through the large-scale aggregation of eye lens proteins as a result of ageing or congenital mutations. The development of new treatments is hindered by uncertainty about the nature of the aggregates and their mechanism of formation. We describe the structure and morpholo...

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Detaylı Bibliyografya
Yayımlandı:Nat Commun
Asıl Yazarlar: Boatz, Jennifer C., Whitley, Matthew J., Li, Mingyue, Gronenborn, Angela M., van der Wel, Patrick C. A.
Materyal Türü: Artigo
Dil:Inglês
Baskı/Yayın Bilgisi: Nature Publishing Group 2017
Konular:
Online Erişim:https://ncbi.nlm.nih.gov/pmc/articles/PMC5424181/
https://ncbi.nlm.nih.gov/pubmed/28474685
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/ncomms15137
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