Inhibition of hepatic lipogenesis enhances liver tumorigenesis by increasing antioxidant defence and promoting cell survival

The metabolic pathway of de novo lipogenesis is frequently upregulated in human liver tumours, and its upregulation is associated with poor prognosis. Blocking lipogenesis in cultured liver cancer cells is sufficient to decrease cell viability; however, it is not known whether blocking lipogenesis i...

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Veröffentlicht in:Nat Commun
Hauptverfasser: Nelson, Marin E., Lahiri, Sujoy, Chow, Jenny D. Y., Byrne, Frances L., Hargett, Stefan R., Breen, David S., Olzomer, Ellen M., Wu, Lindsay E., Cooney, Gregory J., Turner, Nigel, James, David E., Slack-Davis, Jill K., Lackner, Carolin, Caldwell, Stephen H., Hoehn, Kyle L.
Format: Artigo
Sprache:Inglês
Veröffentlicht: Nature Publishing Group 2017
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Article
Online Zugang:https://ncbi.nlm.nih.gov/pmc/articles/PMC5424065/
https://ncbi.nlm.nih.gov/pubmed/28290443
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/ncomms14689
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