Genetic inhibition of hepatic acetyl-CoA carboxylase activity increases liver fat and alters global protein acetylation()

Lipid deposition in the liver is associated with metabolic disorders including fatty liver disease, type II diabetes, and hepatocellular cancer. The enzymes acetyl-CoA carboxylase 1 (ACC1) and ACC2 are powerful regulators of hepatic fat storage; therefore, their inhibition is expected to prevent the...

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Main Authors: Chow, Jenny D.Y., Lawrence, Robert T., Healy, Marin E., Dominy, John E., Liao, Jason A., Breen, David S., Byrne, Frances L., Kenwood, Brandon M., Lackner, Carolin, Okutsu, Saeko, Mas, Valeria R., Caldwell, Stephen H., Tomsig, Jose L., Cooney, Gregory J., Puigserver, Pere B., Turner, Nigel, James, David E., Villén, Judit, Hoehn, Kyle L.
Format: Artigo
Jezik:Inglês
Izdano: Elsevier 2014
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Original Article
Online dostop:https://ncbi.nlm.nih.gov/pmc/articles/PMC4060285/
https://ncbi.nlm.nih.gov/pubmed/24944901
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.molmet.2014.02.004
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