Genetic inhibition of hepatic acetyl-CoA carboxylase activity increases liver fat and alters global protein acetylation()

Lipid deposition in the liver is associated with metabolic disorders including fatty liver disease, type II diabetes, and hepatocellular cancer. The enzymes acetyl-CoA carboxylase 1 (ACC1) and ACC2 are powerful regulators of hepatic fat storage; therefore, their inhibition is expected to prevent the...

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Hlavní autoři: Chow, Jenny D.Y., Lawrence, Robert T., Healy, Marin E., Dominy, John E., Liao, Jason A., Breen, David S., Byrne, Frances L., Kenwood, Brandon M., Lackner, Carolin, Okutsu, Saeko, Mas, Valeria R., Caldwell, Stephen H., Tomsig, Jose L., Cooney, Gregory J., Puigserver, Pere B., Turner, Nigel, James, David E., Villén, Judit, Hoehn, Kyle L.
Médium: Artigo
Jazyk:Inglês
Vydáno: Elsevier 2014
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Original Article
On-line přístup:https://ncbi.nlm.nih.gov/pmc/articles/PMC4060285/
https://ncbi.nlm.nih.gov/pubmed/24944901
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.molmet.2014.02.004
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