Genetic inhibition of hepatic acetyl-CoA carboxylase activity increases liver fat and alters global protein acetylation()

Lipid deposition in the liver is associated with metabolic disorders including fatty liver disease, type II diabetes, and hepatocellular cancer. The enzymes acetyl-CoA carboxylase 1 (ACC1) and ACC2 are powerful regulators of hepatic fat storage; therefore, their inhibition is expected to prevent the...

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Main Authors: Chow, Jenny D.Y., Lawrence, Robert T., Healy, Marin E., Dominy, John E., Liao, Jason A., Breen, David S., Byrne, Frances L., Kenwood, Brandon M., Lackner, Carolin, Okutsu, Saeko, Mas, Valeria R., Caldwell, Stephen H., Tomsig, Jose L., Cooney, Gregory J., Puigserver, Pere B., Turner, Nigel, James, David E., Villén, Judit, Hoehn, Kyle L.
Format: Artigo
Sprog:Inglês
Udgivet: Elsevier 2014
Fag:
Original Article
Online adgang:https://ncbi.nlm.nih.gov/pmc/articles/PMC4060285/
https://ncbi.nlm.nih.gov/pubmed/24944901
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.molmet.2014.02.004
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