Inhibition of hepatic lipogenesis enhances liver tumorigenesis by increasing antioxidant defence and promoting cell survival

The metabolic pathway of de novo lipogenesis is frequently upregulated in human liver tumours, and its upregulation is associated with poor prognosis. Blocking lipogenesis in cultured liver cancer cells is sufficient to decrease cell viability; however, it is not known whether blocking lipogenesis i...

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Udgivet i:Nat Commun
Main Authors: Nelson, Marin E., Lahiri, Sujoy, Chow, Jenny D. Y., Byrne, Frances L., Hargett, Stefan R., Breen, David S., Olzomer, Ellen M., Wu, Lindsay E., Cooney, Gregory J., Turner, Nigel, James, David E., Slack-Davis, Jill K., Lackner, Carolin, Caldwell, Stephen H., Hoehn, Kyle L.
Format: Artigo
Sprog:Inglês
Udgivet: Nature Publishing Group 2017
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Article
Online adgang:https://ncbi.nlm.nih.gov/pmc/articles/PMC5424065/
https://ncbi.nlm.nih.gov/pubmed/28290443
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/ncomms14689
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