PDE2A2 regulates mitochondria morphology and apoptotic cell death via local modulation of cAMP/PKA signalling

cAMP/PKA signalling is compartmentalised with tight spatial and temporal control of signal propagation underpinning specificity of response. The cAMP-degrading enzymes, phosphodiesterases (PDEs), localise to specific subcellular domains within which they control local cAMP levels and are key regulat...

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Pubblicato in:eLife
Autori principali: Monterisi, Stefania, Lobo, Miguel J, Livie, Craig, Castle, John C, Weinberger, Michael, Baillie, George, Surdo, Nicoletta C, Musheshe, Nshunge, Stangherlin, Alessandra, Gottlieb, Eyal, Maizels, Rory, Bortolozzi, Mario, Micaroni, Massimo, Zaccolo, Manuela
Natura: Artigo
Lingua:Inglês
Pubblicazione: eLife Sciences Publications, Ltd 2017
Soggetti:
Cell Biology
Accesso online:https://ncbi.nlm.nih.gov/pmc/articles/PMC5423767/
https://ncbi.nlm.nih.gov/pubmed/28463107
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.7554/eLife.21374
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