Small molecule p300/catenin antagonist enhances hematopoietic recovery after radiation

There is currently no FDA approved therapeutic agent for ARS mitigation post radiation exposure. Here we report that the small molecule YH250, which specifically antagonizes p300/catenin interaction, stimulates hematopoiesis in lethally or sublethally irradiated mice. A single administration of YH25...

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Publicat a:PLoS One
Autors principals: Zhao, Yi, Wu, Kaijin, Nguyen, Cu, Smbatyan, Goar, Melendez, Elisabeth, Higuchi, Yusuke, Chen, Yibu, Kahn, Michael
Format: Artigo
Idioma:Inglês
Publicat: Public Library of Science 2017
Matèries:
Research Article
Accés en línia:https://ncbi.nlm.nih.gov/pmc/articles/PMC5423697/
https://ncbi.nlm.nih.gov/pubmed/28486541
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1371/journal.pone.0177245
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