Small molecule p300/catenin antagonist enhances hematopoietic recovery after radiation

There is currently no FDA approved therapeutic agent for ARS mitigation post radiation exposure. Here we report that the small molecule YH250, which specifically antagonizes p300/catenin interaction, stimulates hematopoiesis in lethally or sublethally irradiated mice. A single administration of YH25...

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Detalhes bibliográficos
Publicado no:PLoS One
Main Authors: Zhao, Yi, Wu, Kaijin, Nguyen, Cu, Smbatyan, Goar, Melendez, Elisabeth, Higuchi, Yusuke, Chen, Yibu, Kahn, Michael
Formato: Artigo
Idioma:Inglês
Publicado em: Public Library of Science 2017
Assuntos:
Research Article
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC5423697/
https://ncbi.nlm.nih.gov/pubmed/28486541
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1371/journal.pone.0177245
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