CBP/Catenin Antagonist Safely Eliminates Drug Resistant Leukemia Initiating Cells

CBP and p300 are highly homologous transcriptional coactivators with unique, non-redundant roles that bind a wide array of proteins, including catenins – β and γ. ICG-001 is a small molecule inhibitor that specifically inhibits the CBP/catenin interaction. Importantly, ICG-001 does not inhibit the p...

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Detalhes bibliográficos
Publicado no:Oncogene
Main Authors: Zhao, Yi, Masiello, David, McMillian, Michael, Nguyen, Cu, Wu, Yongfeng, Melendez, Elizabeth, Smbatyan, Goar, Kida, Aiko, He, Yumin, Teo, Jia-Ling, Kahn, Michael
Formato: Artigo
Idioma:Inglês
Publicado em: 2015
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Article
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC5526055/
https://ncbi.nlm.nih.gov/pubmed/26657156
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/onc.2015.438
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