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CBP/Catenin Antagonist Safely Eliminates Drug Resistant Leukemia Initiating Cells
CBP and p300 are highly homologous transcriptional coactivators with unique, non-redundant roles that bind a wide array of proteins, including catenins – β and γ. ICG-001 is a small molecule inhibitor that specifically inhibits the CBP/catenin interaction. Importantly, ICG-001 does not inhibit the p...
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| 發表在: | Oncogene |
|---|---|
| Main Authors: | , , , , , , , , , , |
| 格式: | Artigo |
| 語言: | Inglês |
| 出版: |
2015
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| 主題: | |
| 在線閱讀: | https://ncbi.nlm.nih.gov/pmc/articles/PMC5526055/ https://ncbi.nlm.nih.gov/pubmed/26657156 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/onc.2015.438 |
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