Selective inhibition of tumor cell associated Vacuolar‐ATPase ‘a2’ isoform overcomes cisplatin resistance in ovarian cancer cells

Development of resistance to platinum compounds significantly hinders successful ovarian cancer (OVCA) treatment. In tumor cells, dysregulated pH gradient across cell membranes is a key physiological mechanism of metastasis/chemo‐resistance. These pH alterations are mediated by aberrant activation o...

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Publicado no:Mol Oncol
Main Authors: Kulshrestha, Arpita, Katara, Gajendra K., Ginter, Jordyn, Pamarthy, Sahithi, Ibrahim, Safaa A., Jaiswal, Mukesh K., Sandulescu, Corina, Periakaruppan, Ramayee, Dolan, James, Gilman-Sachs, Alice, Beaman, Kenneth D.
Formato: Artigo
Idioma:Inglês
Publicado em: John Wiley and Sons Inc. 2016
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Articles
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC5423172/
https://ncbi.nlm.nih.gov/pubmed/26899534
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.molonc.2016.01.003
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