Selective inhibition of tumor cell associated Vacuolar‐ATPase ‘a2’ isoform overcomes cisplatin resistance in ovarian cancer cells

Development of resistance to platinum compounds significantly hinders successful ovarian cancer (OVCA) treatment. In tumor cells, dysregulated pH gradient across cell membranes is a key physiological mechanism of metastasis/chemo‐resistance. These pH alterations are mediated by aberrant activation o...

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Veröffentlicht in:Mol Oncol
Hauptverfasser: Kulshrestha, Arpita, Katara, Gajendra K., Ginter, Jordyn, Pamarthy, Sahithi, Ibrahim, Safaa A., Jaiswal, Mukesh K., Sandulescu, Corina, Periakaruppan, Ramayee, Dolan, James, Gilman-Sachs, Alice, Beaman, Kenneth D.
Format: Artigo
Sprache:Inglês
Veröffentlicht: John Wiley and Sons Inc. 2016
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Articles
Online Zugang:https://ncbi.nlm.nih.gov/pmc/articles/PMC5423172/
https://ncbi.nlm.nih.gov/pubmed/26899534
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.molonc.2016.01.003
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