Vacuolar ATPase ‘a2’ isoform exhibits distinct cell surface accumulation and modulates matrix metalloproteinase activity in ovarian cancer

Tumor associated vacuolar H+-ATPases (V-ATPases) are multi-subunit proton pumps that acidify tumor microenvironment, thereby promoting tumor invasion. Subunit ‘a’ of its V0 domain is the major pH sensing unit that additionally controls sub-cellular targeting of V-ATPase and exists in four different...

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Detalles Bibliográficos
Publicado en:Oncotarget
Main Authors: Kulshrestha, Arpita, Katara, Gajendra K., Ibrahim, Safaa, Pamarthy, Sahithi, Jaiswal, Mukesh K., Sachs, Alice Gilman, Beaman, Kenneth D.
Formato: Artigo
Idioma:Inglês
Publicado: Impact Journals LLC 2015
Assuntos:
Research Paper
Acceso en liña:https://ncbi.nlm.nih.gov/pmc/articles/PMC4414154/
https://ncbi.nlm.nih.gov/pubmed/25686833
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