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EMT is associated with, but does not drive resistance to ALK inhibitors among EML4‐ALK non‐small cell lung cancer

ALK gene fusion occurs in approximately 3–7% of non‐small cell lung cancer (NSCLC). For patients with ALK positive NCSLC, crizotinib and ceritinib are FDA approved ALK inhibitors, however, patients inevitably acquire resistance to such therapies typically within one to two years. Interrogation of in...

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Bibliografiska uppgifter
I publikationen:Mol Oncol
Huvudupphovsmän: Gower, Arjan, Hsu, Wei-Hsun, Hsu, Shuo-Tse, Wang, Yisong, Giaccone, Giuseppe
Materialtyp: Artigo
Språk:Inglês
Publicerad: John Wiley and Sons Inc. 2015
Ämnen:
Länkar:https://ncbi.nlm.nih.gov/pmc/articles/PMC5423150/
https://ncbi.nlm.nih.gov/pubmed/26639656
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.molonc.2015.11.007
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