CRKL mediates EML4-ALK signaling and is a potential therapeutic target for ALK-rearranged lung adenocarcinoma

Anaplastic lymphoma kinase (ALK) gene rearrangements are oncogenic drivers in a small subset of patients with non-small-cell lung cancer (NSCLC). The ALK inhibitors are highly effective in NSCLC patients harboring ALK rearrangements; however, most patients acquire resistance to the therapy following...

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Udgivet i:Oncotarget
Main Authors: An, Rong, Wang, Yisong, Voeller, Donna, Gower, Arjan, Kim, In-Kyu, Zhang, Yu-Wen, Giaccone, Giuseppe
Format: Artigo
Sprog:Inglês
Udgivet: Impact Journals LLC 2016
Fag:
Research Paper
Online adgang:https://ncbi.nlm.nih.gov/pmc/articles/PMC5045389/
https://ncbi.nlm.nih.gov/pubmed/27078848
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.18632/oncotarget.8638
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