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VCP inhibitors induce endoplasmic reticulum stress, cause cell cycle arrest, trigger caspase‐mediated cell death and synergistically kill ovarian cancer cells in combination with Salubrinal

Valosin‐containing protein (VCP) or p97, a member of AAA‐ATPase protein family, has been associated with various cellular functions including endoplasmic reticulum‐associated degradation (ERAD), Golgi membrane reassembly, autophagy, DNA repair, and cell division. Recent studies identified VCP and ub...

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Bibliografski detalji
Izdano u:Mol Oncol
Glavni autori: Bastola, Prabhakar, Neums, Lisa, Schoenen, Frank J., Chien, Jeremy
Format: Artigo
Jezik:Inglês
Izdano: John Wiley and Sons Inc. 2016
Teme:
Online pristup:https://ncbi.nlm.nih.gov/pmc/articles/PMC5423134/
https://ncbi.nlm.nih.gov/pubmed/27729194
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.molonc.2016.09.005
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