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VCP inhibitors induce endoplasmic reticulum stress, cause cell cycle arrest, trigger caspase‐mediated cell death and synergistically kill ovarian cancer cells in combination with Salubrinal

Valosin‐containing protein (VCP) or p97, a member of AAA‐ATPase protein family, has been associated with various cellular functions including endoplasmic reticulum‐associated degradation (ERAD), Golgi membrane reassembly, autophagy, DNA repair, and cell division. Recent studies identified VCP and ub...

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Podrobná bibliografie
Vydáno v:Mol Oncol
Hlavní autoři: Bastola, Prabhakar, Neums, Lisa, Schoenen, Frank J., Chien, Jeremy
Médium: Artigo
Jazyk:Inglês
Vydáno: John Wiley and Sons Inc. 2016
Témata:
On-line přístup:https://ncbi.nlm.nih.gov/pmc/articles/PMC5423134/
https://ncbi.nlm.nih.gov/pubmed/27729194
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.molonc.2016.09.005
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