Anti-apoptotic proteins BCL-2, MCL-1 and A1 summate collectively to maintain survival of immune cell populations both in vitro and in vivo

Survival of various immune cell populations has been proposed to preferentially rely on a particular anti-apoptotic BCL-2 family member, for example, naive T cells require BCL-2, while regulatory T cells require MCL-1. Here we examined the survival requirements of multiple immune cell subsets in vit...

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Udgivet i:Cell Death Differ
Main Authors: Carrington, Emma M, Zhan, Yifan, Brady, Jamie L, Zhang, Jian-Guo, Sutherland, Robyn M, Anstee, Natasha S, Schenk, Robyn L, Vikstrom, Ingela B, Delconte, Rebecca B, Segal, David, Huntington, Nicholas D, Bouillet, Philippe, Tarlinton, David M, Huang, David CS, Strasser, Andreas, Cory, Suzanne, Herold, Marco J, Lew, Andrew M
Format: Artigo
Sprog:Inglês
Udgivet: Nature Publishing Group 2017
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Original Paper
Online adgang:https://ncbi.nlm.nih.gov/pmc/articles/PMC5423112/
https://ncbi.nlm.nih.gov/pubmed/28362427
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/cdd.2017.30
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